Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma

Table 5 Performance of the radiomics models to differentiate between tumor, PTA and PTD of ESCC

Pairwise tissues	Cohort	AUC (95%CI)	Accuracy	F1-score	Sensitivity	Specificity	PPV	NPV
Tumor vs. PTA	TC	0.965 (0.950-0.979)	0.965	0.965	0.974	0.955	0.956	0.974
	IVC	0.956 (0.931-0.980)	0.956	0.955	0.948	0.963	0.962	0.949
	EVC	0.962 (0.939-0.985)	0.937	0.935	0.904	0.970	0.968	0.910
Tumor vs. PTD	TC	0.991 (0.985-0.997)	0.958	0.959	0.971	0.949	0.953	0.964
	IVC	0.990 (0.979-1.000)	0.952	0.951	0.970	0.948	0.946	0.969
	EVC	0.974 (0.955-0.993)	0.970	0.969	0.970	0.978	0.977	0.963
PTA vs. PTD	TC	0.870 (0.841-0.898)	0.848	0.838	0.785	0.910	0.897	0.809
	IVC	0.806 (0.632-0.980)	0.760	0.759	0.714	0.929	0.865	0.769
	EVC	0.786 (0.630-0.941)	0.786	0.769	0.714	0.857	0.833	0.750

ESCC esophageal squamous cell carcinoma, PTA proximal tumor-adjacent tissue, PTD proximal tumor-distant tissue, TC training cohort, IVC internal validation cohort, EVC external validation cohort, AUC area under the receiver operating characteristic curve, 95%CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value

ISSN: 1470-7330