Effect of Hashimoto’s thyroiditis on the dual-energy CT quantitative parameters and performance in diagnosing metastatic cervical lymph nodes in patients with papillary thyroid cancer

Table 5 Diagnostic performance of dual-energy CT parameters in differentiating lateral metastatic from nonmetastatic lymph nodes in PTC patients with and without HT

	Threshold	AUC	Sensitivity	Specificity
HT+/LLN + vs. HT+/LLN-
IC_A (mg/mL) NIC_A Z_effA λ_HUA IC_V (mg/mL) NIC_V Z_effV	1.550 0.193 8.350 3.398 2.950 0.523 8.950	0.780 0.780 0.780 0.800 0.668 0.649 0.644	0.792 0.792 0.792 0.792 0.417 0.542 0.417	0.638 0.698 0.638 0.711 0.966 0.765 0.946
HT-/LLN + vs. HT-/LLN-
IC_A (mg/mL) NIC_A Z_effA λ_HUA IC_V (mg/mL) NIC_V Z_effV λ_HUV	2.050 0.226 8.550 4.310 2.250 0.577 8.750 4.601	0.980 0.989 0.978 0.971 0.926 0.952 0.922 0.914	0.914 0.971 0.914 0.914 0.886 0.829 0.829 0.886	0.977 0.969 0.969 0.969 0.855 0.962 0.901 0.878

Note: PTC, papillary thyroid cancer; HT, Hashimoto’s thyroiditis; HT+, PTC with HT; HT-, PTC without HT; LLN+, metastatic lateral lymph nodes; LLN-, nonmetastatic LLNs; IC_A/IC_v, iodine concentration in arterial/venous phase; NIC_A/NIC_V, normalized IC_A/IC_v; λ_HUA/λ_HUV, slope of the spectral Hounsfield unit curve in arterial/venous phase; Z_effA/Z_effV, effective atomic number in arterial/venous phase. AUC, area under the curve
Threshold IC_A/IC_v are represented as mg/mL

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