3D analysis of apparent diffusion coefficient histograms in hepatocellular carcinoma: correlation with histological grade

Table 3 Histological grade of hepatocellular carcinoma (after excluding steatosis lesions), the ADC histogram parameters, Pearson’s product moment correlation coefficient, and one-way ANOVA with the Tukey-Kramer post hoc test

	Well diff HCC	Mod diff HCC	Poor diff HCC	Pearson’s correlation coefficient	Pearson’s correlation coefficient P value	ANOVA Tukey-Kramer post hoc test
Mean	1071 ± 178	1004 ± 157	967 ± 176	−0.164	0.281	n.s.
Standard deviation	147 ± 86	196 ± 89	243 ± 76	0.290	0.053	n.s.
Minimum	738 ± 322	421 ± 271	221 ± 110	−0.469	0.001*	0.006**
Maximum	1588 ± 493	1787 ± 579	1808 ± 606	0.201	0.186	n.s.
Mode	582 ± 531	890 ± 281	799 ± 347	0.122	0.425	n.s.
Skewness	0.91 ± 1.40	0.54 ± 0.84	0.59 ± 0.94	−0.073	0.633	n.s.
Kurtosis	5.39 ± 5.45	5.10 ± 3.38	5.50 ± 3.61	0.017	0.912	n.s.
5th percentile	910 ± 187	734 ± 181	631 ± 158	−0.382	0.010*	0.03***
50th percentile	1042 ± 163	997 ± 154	934 ± 160	−0.192	0.205	n.s.
75th percentile	1139 ± 222	1119 ± 173	1089 ± 199	−0.078	0.610	n.s.
90th percentile	1218 ± 217	1244 ± 219	1271 ± 260	0.065	0.672	n.s.

Well diff HCC: Well differentiated hepatocellular carcinoma
Mod diff HCC: Moderately differentiated hepatocellular carcinoma
Poor diff HCC: Poorly differentiated hepatocellular carcinoma
*, **, *** P < 0.05
n.s. no significant difference
**Tukey-Kramer post hoc test: Well diff HCC vs Mod diff HCC, P = 0.187; Well diff HCC vs Poor diff HCC, P = 0.045; Mod diff HCC vs Poor diff HCC, P = 0.008
***Tukey-Kramer post hoc test: Well diff HCC vs Mod diff HCC, P = 0.110; Well diff HCC vs Poor diff HCC, P = 0.023; Mod diff HCC vs Poor diff HCC, P = 0.317

ISSN: 1470-7330