Table 1 Soft tissue sarcoma molecular subtypes
From: Translational research in diagnosis and management of soft tissue tumours
STS with simple genomics | More frequent translocations | STS with complex genomics |
|---|---|---|
Ewing sarcoma family (ES/PNET) | t(11;22)(q24;q12) | Malignant peripheral nerve-sheath tumor (MPNST) |
Desmoplastic Small Round Cell Tumor (DSRCT) | t(11;22)(p13;q12) | Undifferentiated Pleomorphic Sarcoma (UPS) |
Alveolar soft part sarcoma | t(X;17)(p11;q25) | Fibrosarcoma (FS) |
Congenital fibrosarcoma | t(12;15)(p13;q25) | Pleomorphic Liposarcoma (PLPS) |
Myxoid Liposarcoma (LPS) | t(12;16)(q13;p11) | Leiomyosarcoma (LMS) |
Malignant melanoma of soft parts | t(12;22)(q13;q12) | Embryonal/Pleomorphic RMS (ERMA/PRMS) |
Synovial sarcoma (SS) | t(X;18)(p11.23;q11) | Angiosarcoma Myxofibrosarcoma (MFS) |
Alveolar Rhabdomyosarcoma (ARMS) | t(2;13)(q35;q14) | Osteosarcoma (OS) |
DermatoFibroSarcoma Protuberance (DFSP) | t(17;22)(q22;q13) | Â |
Epithelioid hemangioendothelioma | t(1;3)(p36.3;q25) | Â |
Mesoblastic nephroma | t(12;15)(p13;q25) | Â |
Clear cell sarcoma (CCS) | t(12;22)(q13;q12) | Â |
Angiomatoid fibrous histiocytoma | t(12;16)(q13;p11) | Â |
Low grade fibromyxoid sarcoma | t(7;16)(q32;p11) | Â |
Endometrial stromal sarcoma | t(7;17)(p15;q21) | Â |
Inflammatory myofibroblastic tumor | t(1;2)(q25;p23) | Â |
Giant-cell fibroblastoma | t(17;22)(q22;q13) | Â |
Extraskeletal myxoid chondrosarcoma | t(9;22)(q22;q12) | Â |