Fig. 5
From: Multi-modal imaging of tumor cellularity and Tryptophan metabolism in human Gliomas
Receiver operating characteristic (ROC) curve analysis was applied to estimate the optimal cut-off value of IDSI-cellularity (0.17), yielding the accuracy/sensitivity/specificity of 0.80/0.80/0.80 to differentiate grade IV gliomas from grade II gliomas. The detection of the proliferating tumor cells was performed by thresholding of IDSI-derived cellularity at its cut-off value. Red-colored voxels survived the cutoff threshold inside the FLAIR hyperintense tumor regions (1st row) and the AMT high uptake regions (2nd row). For the comparison, the detection of the proliferating tumor cells inside the FLAIR hyperintense tumor regions was performed by thresholding of DWI-ADC image at two cut-off values, 0.93 × 10−3 mm2/s (3rd row) and 1.22 × 10−3 mm2/s (4th row) which were reported as the ADC values for hypercelluarity previously validated by histology [14, 21]